Diagnosing and treating Neurosyphilis , a serious complication of syphilis where the infection spreads to the brain and nervous system, requires adherence to current guidelines. The Centers for Disease Control and Prevention (CDC) provides comprehensive recommendations for managing this condition across its various clinical presentations. This blog outlines the key aspects of these guidelines to enhance understanding of Neurosyphilis diagnosis and treatment protocols used by healthcare professionals. Lumbar Puncture: Essential for Neurosyphilis Diagnosis According to current CDC guidelines, a lumbar puncture (spinal tap) is strongly recommended for the diagnosis of Neurosyphilis in most cases. Cerebrospinal fluid (CSF) analysis, including tests for Venereal Disease Research Laboratory (VDRL) and fluorescent treponemal antibody absorption (FTA-ABS), is crucial for confirming central nervous system involvement. However, in some cases of late N...